39 illustrates how ERG binding demands a conformational alter to support the phenyl ring of ERG. Insert displays schematic illustrating that different ergoline substituents (R, pink circle) and their interactions with the receptor very likely determine the orientation from the ergoline scaffold, which seems to be able to rotate round https://dmtcarts.store/product/5-meo-dmtcartridge-and-battery-5ml-deadhead-chemist