Buffalo Museum of Science weather). Typically, it opens up at 10 AM and closes at 5 PM, but weekend breaks may have extended hours Exist Any Kind Of Admission Discount Rates Available? Yes, you can locate admission discount rates at the museum. Appreciate your visit! Is the Museum Wheelchair Accessible? https://buffalo-museum-of-science42468.anchor-blog.com/15372484/take-your-kids-to-the-buffalo-museum-of-science-for-an-exciting-day-out